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In developed countries, we've mostly eliminated freeloaders like parasitic¹ worms from our guts³. But we also have the highest rates of inflammatory bowel⁴ disease, or IBD—when the immune system mistakenly attacks intestinal⁵ cells and friendly gut² bacteria.

 

For years, docs suspected there might be a connection between IBD and our worm-free lifestyle. And a handful of studies have actually shown that infecting human patients with worms can reduce symptoms of the disease. But how?

 

To find out, researchers fed parasitic worm eggs to monkeys with chronic⁶ diarrhea and gut inflammation—similar to IBD. After infection, the monkeys' immune systems kicked into high gear, pumping out more mucus than usual to fight the worms. But that response also helped heal the monkeys' intestines—restoring healthy, diverse populations of gut bacteria and decreasing the diarrhea. Those results appear in the journal PLoS Pathogens.

 

The researchers already have FDA approval to study the worms in human subjects. Interested patients can go to clinicaltrials.gov to sign up—and hopefully worm their way out of intestinal distress⁷.

 

Thanks for the minute. From Scientific American 60 Second Science. I am Christopher Intagliata.

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