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   LONDON, Aug. 11 (Xinhua) -- For young people at high risk of developing schizophrenia, a 12-week intervention1 with omega-3 supplements might reduce the long-term risk of progression to the psychotic disorder2, according to a paper published Tuesday in the journal Nature Communications.

  Researchers from Australia and Austria carried out research over nearly seven years on the effect of omega-3 on the risk of psychotic disorder.
  Schizophrenia typically manifests in adolescence3 or early adulthood4 and the majority of those affected5 gradually develop a variety of clinically significant signs and symptoms. Diagnostic criteria6, termed "ultra-high risk" criteria have been developed to identify young people more likely to develop psychosis.
  Omega-3 supplements may reduce psychosis risk: researchers
  Previous studies have implicated7 a lack of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) in the development of a number of mental health conditions and several trials have shown that supplementation with omega-3 PUFAs can reduce psychotic symptoms.
  In 2010, researchers reported that dietary supplements of omega-3 PUFAs, in participants aged8 13 to 25, prevented a first episode of a psychotic disorder for up to one year.
  The new report showed that this intervention had long-term effects even after a period of 6.7 years for 71 of the original 81 participants. They found that 9.8 percent of the omega-3 group (4 out 41) developed psychosis compared to 40 percent (16 out of 40) in the placebo9 group. In addition, the placebo group showed more rapid onset10 of psychosis and a higher overall incidence of other psychiatric disorders11.
  But due to the limited size of the sample group, further research was necessary to discover a mechanism12 by which PUFA supplementation might improve mental health, the researchers also said.

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