A win would give Real Madrid an unassailable seven point lead over FC Barcelona with just two matches left in the season. Meanwhile should Barcelona fail to win their home game against Malaga, a draw would be enough to give Madrid the title.

　　Jose Mourinho's side cannot expect an easy night in San Mames, however, Athletic have had a magnificent campaign and their fans are rightly angry at Real Madrid's decision to refuse the final of the Copa del Rey, in which Athletic will play Barca, to be played in the Santiago Bernabeu Stadium.

　　Madrid allege work to repair the bathrooms in the Stadium, but most believe it is because the club do not want to see Barcelona win a title on their home turf. The decision means the final will now be played in the Vicente Calderon Stadium, which has a capacity of around 27,000 less than the Bernabeu.

　　As a result thousands of Athletic fans will be unable to view the final in person and as they hold Madrid President, Florentino Perez directly responsible, his players can also expect a hostile reception.

　　Regarding team news, Athletic are without suspended duo Ander Herrera and Ander Iturraspe, through suspension, while Angel De Maria is out for the same reason for Madrid.

　　Barcelona meanwhile play at home to Malaga in what is a vital game for the visitors, who are level on points with third placed Valencia and aiming to qualify directly for the Champions League.

　　It promises to be an emotional night as the fans in the Camp Nou give their thanks to Pep Guardiola, who will leave his post as coach at the end of the season.

　　On Wednesday's other games, Valencia are at home to Osasuna, who still hold hopes of a place in Europe. There will be drama in the La Romareda Stadium, where Zaragoza look to continue their recovery at home to a Levante side that also has Champions League ambitions.

　　Atletico Madrid can afford no slip ups at home to a Real Sociedad that has nothing to play for. Atletico can still finish in the top four, but a top six finish has to be their realistic aim.

　　Rayo Vallecano still need a win to be assured of avoiding relegation, but face a difficult trip to play Mallorca, while the Seville derby between Sevilla and Betis is certain to be a passionate affair between two sides, who may be neighbors, but who are far from being friends.