New Treatment Could Prevent, Reverse Alzheimer’s

New Treatment Could Prevent, Reverse Alzheimer’s

New research suggests that a brain protein that has changed form may be the cause of brain disorders¹ -- including Alzheimer’s Disease. Researchers say they have developed a treatment that may cause the protein to return to its original form, preventing the disease from developing or reversing the effects of the damage in people who already suffer from Alzheimer’s.

Researchers at Beth Israel Deaconess Medical Center in Boston, Massachusetts, found that the shape of the protein -- which is called “tau” -- is changed by severe injuries to the brain. The scientists say when people are hit in the head many times, they develop a condition called chronic² traumatic encephalopathy, or CTE.

CTE develops in soldiers with head injuries. People who play American football also suffer from CTE after being hit in the head many times. The memory, judgment³ and ability to function are affected⁴ in people with CTE.

Alvaro Pascual-Leone is a neurologist -- a brain scientist. He was one of the researchers who discovered the effect of brain injuries on the “tau” protein.

“We know that the tau plays a key role in Alzheimer’s disease. And so it is possible that also there, in the absence of traumatic brain injury, one might be able to protect the brain from the damage in the progression of the disease.”

The researchers recently published an article about their findings in the journal Nature. Mr. Pascual-Leone and his colleagues reported that they had developed a treatment that returns the damaged tau to its original, undamaged form. He says it might be possible to use the treatment to stop the development of Alzheimer’s Disease. And he suggests it could also slow the loss of brain function in people who already have the disease.

“If we were able to slow down the progression or to modify the course of the disease, it would have a big impact on the well-being⁵ of the patients and their families.”

Scientists discovered the tau in mice that suffered brain injuries began changing form in as little as 12 hours after the mice were hit in the head.

Researchers hope to develop a blood test or use machines that can see into the brain to help them identify changed tau. Early identification of the problem in people with brain injury could help doctors treat them quickly and stop the tau from changing.

Words in This Story

form – n. the shape of something

reverse – v. to cause (something, such as a process) to stop or return to an earlier state

function – n. the special purpose or activity for which a thing exists or is used

key – adj. extremely important

absence – n. a state or condition in which something expected, wanted or looked for is not present or does not exist; a state or condition in which something is absent

traumatic – adj. related to or caused by a severe injury to the body

progression – n. the process of developing over a period of time

modify – v. to change the appearance, direction or progression of something

impact – n. an influence or effect

1 disorders   

n.混乱( disorder的名词复数 )；凌乱；骚乱；（身心、机能）失调

参考例句：

• Reports of anorexia and other eating disorders are on the increase. 据报告，厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
• The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》

2 chronic   

adj.(疾病)长期未愈的，慢性的；极坏的

参考例句：

• Famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
• Chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。

3 judgment   

n.审判；判断力，识别力，看法，意见

参考例句：

• The chairman flatters himself on his judgment of people.主席自认为他审视人比别人高明。
• He's a man of excellent judgment.他眼力过人。

4 affected   

adj.不自然的，假装的

参考例句：

• She showed an affected interest in our subject.她假装对我们的课题感到兴趣。
• His manners are affected.他的态度不自然。

5 well-being   

n.安康，安乐，幸福

参考例句：

• He always has the well-being of the masses at heart.他总是把群众的疾苦挂在心上。
• My concern for their well-being was misunderstood as interference.我关心他们的幸福，却被误解为多管闲事。