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At the Lindau Nobel Laureate meeting in Lindau Germany, this will just take a little time than a usual minute.

Edmond Fischer won the Nobel Prize in Physiology¹ or Medicine in 1992 for his discoveries with Edwin Krebs  about the way protein get activated², and cellular³ processes get regulated, the simple process called phosphorylation.
Now 81 years old, Fischer spoke⁴ to the students at Lindau Nobel Laureate meeting about the difference between research when he was working in the 1950s and the way he conducts today.

Science was conducted in a total different way, in those days, in facts, since the days of clued beyond that, The French physiologists⁵ who first show the glycogenic action of the Pancreas, one observed a physiological⁶ phenomenon and then one tried to detect the fact the enzymes⁸, the hormones⁹, responsible for it.

Where as today, by and larger see other way around, first enzymes proteins are discovered and with completions of I don't know how many genome sequencing.  Projects hundreds of being discovered, then by over-expressing them, knocking them in and out when tries to determine their function.

So to paraphrase¹⁰ xx, we went from 6 functions in search for an an enzyme⁷ to hundreds of enzyme protein, in search of a function.